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Oncology

Prosigna

The Prosigna test is an advanced molecular examination used to assess the risk of breast cancer recurrence in women with early-stage disease. It is based on analyzing gene expression in the tumor and provides essential information to guide treatment decisions.

Overview

The Prosigna test is primarily used to help assess the risk of breast cancer recurrence and is indicated in specific situations. It is based on the tumor’s molecular profile and helps guide treatment decisions.

Number of Women

Number of DR

10-year DR Risk (%)

Prosigna ROR low and Oncotype Dx RS low

104

2

2.1%

Prosigna ROR low, but Oncotype Dx RS intermediate or high

261

7

2.9%

Prosigna ROR intermediate or high, but Oncotype Dx RS low

62

10

18.2%

Prosigna ROR high and Oncotype Dx RS high

55

14

19.5%

Sestak I, Buus R, Cuzick J, et al. JAMA Oncol. 2018; 4(4):545-553

The clinically validated algorithm generates a unique score for each patient.

When Should You Consider This Test?

Consider this test in the following cases:

Patients with early-stage breast cancer
Patients with luminal-type breast cancer
Postmenopausal patients with breast cancer
Assessment of long-term recurrence risk

Note: Prosigna is not indicated for patients with HER2+ tumors or those with estrogen receptor-negative (ER-) tumors, as the test was specifically developed for ER+/HER2- tumors.

Genes Analyzed

The panel includes:

50

Genes

Methodology

The methodology used for this test is as follows:

Sample:

Biopsy

PREPARATION:

Biopsy: In paraffin block or slide

TURNAROUND TIME:

Up to 30 calendar days.

REQUIRED DOCUMENTS:

Medical request.

Type Description
Technique Microarray
Accuracy 80-85%

How to Request the Test?

Auxiliary Documents

Brochure
Report Model
Contact Our Customer Services
Exatus Gene will send a collection kit and provide instructions for sample collection.
We will retrieve the collected sample and send it to the laboratory for analysis.
The report will be made available through the SysGene Portal and sent to your email.