The Prosigna test is an advanced molecular examination used to assess the risk of breast cancer recurrence in women with early-stage disease. It is based on analyzing gene expression in the tumor and provides essential information to guide treatment decisions.
Overview
The Prosigna test is primarily used to help assess the risk of breast cancer recurrence and is indicated in specific situations. It is based on the tumor’s molecular profile and helps guide treatment decisions.
Number of Women
Number of DR
10-year DR Risk (%)
Prosigna ROR low and Oncotype Dx RS low
104
2
2.1%
Prosigna ROR low, but Oncotype Dx RS intermediate or high
261
7
2.9%
Prosigna ROR intermediate or high, but Oncotype Dx RS low
62
10
18.2%
Prosigna ROR high and Oncotype Dx RS high
55
14
19.5%
Sestak I, Buus R, Cuzick J, et al. JAMA Oncol. 2018; 4(4):545-553
The clinically validated algorithm generates a unique score for each patient.
When Should You Consider This Test?
Consider this test in the following cases:
Patients with early-stage breast cancer
Patients with luminal-type breast cancer
Postmenopausal patients with breast cancer
Assessment of long-term recurrence risk
Note: Prosigna is not indicated for patients with HER2+ tumors or those with estrogen receptor-negative (ER-) tumors, as the test was specifically developed for ER+/HER2- tumors.